L'abduction en conception architecturale : une sémiose hypostatique

Cette thèse développe un modèle sémiotique de l’abduction pour représenter un processus de conception architecturale. Elle formalise ce processus par une dualisation hypostatique du rapport sémiotique entre un problème de conception, saisi en tant que signe, et la possibilité de sa matérialisation géométrique. La dualisation réintègre ce signe dans le domaine des systèmes de savoir-concevoir utilisés en conception architecturale, et par conséquent, elle génère de nouvelles solutions architecturales. L’abduction modifie les connaissances préalables engagées dans la production d’une solution (l’hypothèse) et en introduit de nouvelles. La complexité du processus de conception implique, au niveau méthodologique et à partir d’une position épistémologique constructiviste, l’intégration de la subjectivité du concepteur dans le modèle. Ainsi résulte une incertitude des interactions entre problème de conception, production de solution, concepteur et contexte. La sémiotisation de l’abduction architecturale explicite le rôle central de l’interprétation dans la création d’une solution. D’ailleurs, la dualisation s’appuie sur la théorie des possibilités pour opérationnaliser le calcul interprétatif incertain et pour valider les hypothèses générées. En retour, la gestion de la propagation de cette incertitude, dans le modèle sémiotique, facilite l’identification et la formulation des solutions, et rend possible une émergence observationnelle de la nouveauté. Le modèle développé est appliqué à un cas de transformations architecturales géométriques dans un milieu urbain fortement caractérisé.This thesis develops a semiotic model of abduction to represent a process of architectural design. It formalizes this process by the means of a hypostatic dualization, applied to the semiotic relationship between, on the one hand, a design problem, considered as a sign, and on the other, the possibility of its geometric materialization. The dualization reintegrate this sign in the domain of know-how systems used in architectural design, and consequently, it generates new architectural solutions. Abduction modifies and augments the prior knowledge involved in producing the solution (the hypothesis). From a constructivist stance and the ensuing methodological viewpoint, the complexity of the design process implies embedding the designer’s subjectivity in the model. Thus arises an uncertainty about the interactions among design problem, solution production, designer and context. Semiotizing architectural abduction reveals the central role played by interpretation in creating a solution. Besides, dualization relies on possibility theory to formalize the resulting, and uncertain, interpretation calculus, and to validate the obtained hypotheses. In return, managing the uncertainty propagation within the semiotic model, facilitates the identification and the formulation of architectural solutions and allows for an observational emergence of novelty. The developed model is applied to a case of architectural geometric transformations in a heavily characterized neighborhood

Uncovering the role of urinary microbiota in urological tumors : a systematic review of literature

Purpose Urinary microbiota has been found to play a key role in numerous urological diseases. The aim of this systematic review is to depict the role of urinary microbiota in the pathogenesis, diagnosis, prognosis, and treatment of urological tumors, including bladder cancer (BCa), prostate cancer (PCa) and renal cell carcinoma (RCC). Methods A systematic PubMed and Scopus search was undergone from inception through June 2021 for studies investigating urinary microbiota alterations in urological tumors. Study selection followed the PRISMA statement. Phylum, family, genus and species of each bacterium in cancer patients and controls were recorded. Results Twenty-one studies with 1194 patients (748 cancer patients and 446 controls) were included in our final analysis. Certain bacterial phylum, family, genus, and species were more predominant in each of BCa, PCa and RCC patients compared to controls. Abundance and specificity of urinary microbiota were prognosticators for: (1) recurrence, distinguishing recurrent from non-recurrent BCa, (2) disease stage, distinguishing non-muscle invasive from muscle invasive BCa, and (3) disease grade, distinguishing high- vs. low-grade PCa and BCa. Dietary, environmental and geographic patterns influenced urinary microbiota. Urinary microbiota of benign prostatic hyperplasia was different from PCa. Conclusion Urological cancer patients have an altered urinary microbiota compared to controls. This may predict recurrence, disease stage and disease grade of these tumors. Further prospective studies are needed to depict a potential influence on therapeutic outcomes

Uncovering the role of urinary microbiota in urological tumors: a systematic review of literature

Purpose Urinary microbiota has been found to play a key role in numerous urological diseases. The aim of this systematic review is to depict the role of urinary microbiota in the pathogenesis, diagnosis, prognosis, and treatment of urological tumors, including bladder cancer (BCa), prostate cancer (PCa) and renal cell carcinoma (RCC). Methods A systematic PubMed and Scopus search was undergone from inception through June 2021 for studies investigating urinary microbiota alterations in urological tumors. Study selection followed the PRISMA statement. Phylum, family, genus and species of each bacterium in cancer patients and controls were recorded. Results Twenty-one studies with 1194 patients (748 cancer patients and 446 controls) were included in our final analysis. Certain bacterial phylum, family, genus, and species were more predominant in each of BCa, PCa and RCC patients compared to controls. Abundance and specificity of urinary microbiota were prognosticators for: (1) recurrence, distinguishing recurrent from non-recurrent BCa, (2) disease stage, distinguishing non-muscle invasive from muscle invasive BCa, and (3) disease grade, distinguishing high- vs. low-grade PCa and BCa. Dietary, environmental and geographic patterns influenced urinary microbiota. Urinary microbiota of benign prostatic hyperplasia was different from PCa. Conclusion Urological cancer patients have an altered urinary microbiota compared to controls. This may predict recurrence, disease stage and disease grade of these tumors. Further prospective studies are needed to depict a potential influence on therapeutic outcomes